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Anti-RAF1 Antibody Polyclonal
Also for RAF1 (NM_002880)
|C-raf antibody was raised against an 19 amino acid synthetic peptide near the amino terminus of human C-raf.|
|Human, Mouse, Rat
||ELISA, WB: 1 - 2 ug/ml
|C-raf Antibody is supplied in PBS containing 0.02% sodium azide.|
|C-raf Antibody is affinity chromatography purified via peptide column.
|Homo sapiens v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1)|
|c-Raf; CRAF; NS5; Raf-1|
|C-raf Antibody: C-raf is the cellular homolog of viral raf gene (v-raf) and encodes a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases. Once activated, C-raf phosphorylates and activates the protein kinases MEK1 and MEK2, which in turn phosphorylate and activate the serine/threonine specific protein kinases, ERK1 and ERK2. These activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.|
EGFR1 Signaling Pathway
MAPK signaling pathway
Senescence and Autophagy
Wnt Signaling Pathway
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Western blot analysis of C-raf in 3T3 cell lysate with C-raf antibody at (A) 0.5 and (B) 1 ug/mL.