Home Antibody All anti-Ppargc1a antibodies
Also for Ppargc1a (NM_013261)
|Synthetic peptide surrounding amino acid 766 of mouse PGC-1alpha|
|Human, mouse, rat
||WB: 0.5-4 ug/ml
|100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Homo sapiens peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PPARGC1A)|
|LEM6; PGC-1(alpha); PGC-1v; PGC1; PGC1A; PPARGC1|
Entrez Gene 10891 Human
Entrez Gene 19017 Mouse
Entrez Gene 83516 Rat
|The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may also be involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.|
|Transcription FactorsDruggable Genome Insulin signaling pathwayAdipocytokine signaling pathwayHuntington's disease|
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Western blot analysis of PGC-1alpha with Jurkat cell lysate (Lane 1 & 2).