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Home Antibody All anti-PXN antibodies

Anti-PXN PHOSPHO Antibody EP41(2)Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307408
  • Rabbit monoclonal antibody against Paxillin Phospho (pY181) (clone EP41(2)Y ) (Phospho-Specific)
100ul 325 3-7 Days
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WB(1)
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Also for PXN (NM_025157)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic phospho-peptide corresponding to residues surrounding Tyr181 of human Paxillin was used as immunogen. The antibody only detects Paxillin phosphorylated on Tyrosine 181.
Clone NameEP41(2)Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; FC: 1:10 - 1:100
Predicted MW Explanation 64 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse

Reference Data

Target NameHomo sapiens paxillin (PXN), transcript variant 4
Alternative NameFLJ16691
Database LinkNP_079433
Entrez Gene 5829 Human
FunctionPaxillin is a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion) (1). Paxillin plays a significant role in integrin signaling and the tyrosine phosphorylation of paxillin is required for integrin-mediated cytoskeletal reorganization (2). Paxillin is phosphorylated by focal adhesion kinase (FAK) at Tyr118 (3). It has been found that phosphorylation of paxillin at both Tyr118 and Tyr31 is essential for MM1 cancer cell migration (4).
Related PathwayStem cell - PluripotencyDruggable Genome Chemokine signaling pathwayVEGF signaling pathwayFocal adhesionLeukocyte transendothelial migrationRegulation of actin cytoskeleton

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Paxillin (phospho Y181) antibody [EP41(2)Y]; All lanes : Anti-Paxillin (phospho Y181) antibody [EP41(2)Y] at 1/10000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : HeLa cell lysate treated with pervanadate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 64 kDa.Observed band size : 68 kDa .

 

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