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Home Antibody All anti-PTPRC antibodies

Anti-PTPRC TRUEMAB Antibody Clone 3D8

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA506104
  • PTPRC (CD45) mouse monoclonal antibody, Clone 3D8
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401003) , 20ug Explanation
100ul 379 In Stock
CF506104
  • Carrier-free (BSA/glycerol-free) PTPRC mouse monoclonal antibody,clone 3D8
100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type
This antibody qualifies for Season of Giving promotion: Earn $50 Amazon gift card (use promo code SPQ12081) or donation to Cancer.org (promo code SPQ12082) with $600 purchase of UltraMAB or TrueMAB. Click for details
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WB(1)
IHC(2)
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Also for PTPRC (NM_002838)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFull length human recombinant protein of human PTPRC(NP_002829) produced in HEK293T cell.
Clone NameClone 3D8 IsotypeIgG1
Species ReactivityHuman Concentration1 mg/ml
Guaranteed Application *WB, IHC Suggested Dilutions WB 1:1000, IHC 1:150,
Predicted MW Explanation 147.1 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens protein tyrosine phosphatase, receptor type, C (PTPRC), transcript variant 1
Alternative NameB220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200
Database LinkNP_002829
Entrez Gene 5788 Human
FunctionThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012].
Related PathwayES Cell Differentiation/IPSTransmembranePhosphataseDruggable Genome Cell adhesion molecules (CAMs)T cell receptor signaling pathwayFc gamma R-mediated phagocytosisPrimary immunodeficiency

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-PTPRC monoclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).
IHC Image
Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-PTPRC mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506104)
IHC Image
Immunohistochemical staining of paraffin-embedded Human tonsil using anti-PTPRC mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506104)

 

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