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Home Antibody All anti-PTPN11 antibodies

Anti-PTPN11 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306350
  • Rabbit Polyclonal SHP2 Antibody
100ug 325 3-7 Days
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WB(1)
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Also for PTPN11 (NM_002834)
cDNA Clone shRNA/siRNA Primer Pair Protein Antibody

OriGene Data

ImmunogenSHP2 antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human SHP2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens protein tyrosine phosphatase, non-receptor type 11 (PTPN11), transcript variant 1
Alternative NameBPTP3; CFC; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Database LinkNP_002825
FunctionSrc homology-2 domain containing protein (SHP2) is a member of the protein tyrosine phosphatase (PTP) family, a protein family that contains signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. SHP2 contains two tandem Src homology-2 (SH2) domains, which function as phosphotyrosine binding domains either directly or through scaffolding intermediates such as the insulin-receptor substrate 1 (IRS-1). These SH2 domains mediate the interaction of SHP2 with its substrates, allowing SHP2 to dephosphorylate proteins that inhibit signaling kinases such as ERK1 and AKT. SHP2 is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Recent experiments have shown SHP2 plays a significant role in hepatoprotection and liver regeneration.
Related Pathway
EGFR1 Signaling Pathway
Hemostasis
Jak-STAT signaling pathway

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WB Image
Western blot analysis of SHP2 in mouse skeletal muscle tissue lysate with SHP2 antibody at (A) 0.5, (B) 1 and (C) 2 µg/ml.

 

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