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Home Antibody All anti-PTK2B antibodies

Anti-PTK2B Antibody E354

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA303507
  • Rabbit monoclonal antibody against Pyk2 (C-term)(E354)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC406631) , 20ug
100ul 325 3-7 Days
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WB(1)
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Also for PTK2B (NM_173174)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in C-terminus of rat Pyk2 was used as immunogen. The antibody does not cross-react with other Fak family members.
Clone NameE354 IsotypeIgG
Species ReactivityHuman, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:500; IP: 1:50
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%

Reference Data

Target NameHomo sapiens protein tyrosine kinase 2 beta (PTK2B), transcript variant 1
Alternative NameCADTK; CAKB; FADK2; FAK2; PKB; PTK; PYK2; RAFTK
Database LinkNP_775266
FunctionThis gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq].
Related Pathway
EGFR1 Signaling Pathway

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WB Image
Western blot - PYK2 antibody [E354]; Anti-PYK2 antibody [E354] at 1/500 dilution + Jurkat cell lysate.Predicted band size : 116 kDa.Observed band size : 116 kDa.

 

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