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Home Antibody All anti-PTK2 antibodies

Anti-PTK2 Antibody EP1831Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301022
  • Rabbit Monoclonal Antibody against PTK2 (Clone EP1831Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC403521) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for PTK2 (NM_153831)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human FAK were used as an immunogen
Clone NameEP1831Y IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500 2000; IHC: 1: 100 250; ICC: 1: 100 250; FC: 1:30
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens protein tyrosine kinase 2 (PTK2), transcript variant 1
Alternative NameFADK; FAK; FAK1; FRNK; p125FAK; pp125FAK; PPP1R71
Database LinkNP_722560
FunctionFocal adhesion kinase (FAK) is a non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis (1). FAK is composed of a central catalytic domain flanked by large N- and C-terminal regions. FAK is activated by phosphorylation at tyrosine 397 in response to integrin clustering which can be induced by cell adhesion or antibody cross-linking or via G-protein-coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid (2-3). Phosphorylation of FAK Tyr-397 creates a binding site for Src-family kinases, and phosphorylation of FAK Tyr-576/Tyr-577 in the kinase domain activation loop enhances catalytic activity (4). Increased FAK expression has been correlated with the enhanced motility and invasiveness of human tumor cells, as well as with promoting increased cell proliferation (5).
Related Pathway
Focal Adhesion
Hemostasis

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WB Image
Western blot - FAK antibody [EP1831Y]; Anti-FAK antibody [EP1831Y] at 1/500 dilution + HeLa cell lysate at 10 µg.Secondary.HRP labeled goat anti-rabbit at 1/1000 dilution.Predicted band size : 119 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - FAK antibody [EP1831Y]; Immunohistochemical staining of paraffin-embedded human tonsils using 1/100 TA301022

 

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