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Anti-PTGES3 Antibody EPR3846


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against Prostaglandin E Synthase 3 (clone EPR3846 )
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401975) , 20ug Explanation
100ul $325 3-7 Days
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Also for PTGES3 (NM_006601)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Prostaglandin E Synthase 3 was used as an immunogen.
Clone NameEPR3846 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsICC: 1:100 - 250, IP: 1:50, WB: 1:10,000 - 50,000,
Predicted MW Explanation 19 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens prostaglandin E synthase 3 (cytosolic) (PTGES3), transcript variant 1
Alternative NamecPGES; P23; TEBP
Database LinkNP_006592
Entrez Gene 10728 Human
Entrez Gene 56351 Mouse
Entrez Gene 362809 Rat
FunctionProstaglandin E synthase-3 belongs to p23/wos2 family. It is ubiquitously expressed. As one of the two isoforms of the terminal enzymes catalyzing the final step of EG2 biosynthesis, prostaglandin E synthase-3 predominantly converts COX-1-derived PGH2 to PGE2 (1). It is an evolutionarily conserved protein that functions as a component of the Hsp90-based molecular chaperone complex (2). It binds to telomerase and to the progesterone receptor (3). It localizes to genomic response elements in a hormone-dependent manner and represses receptor-mediated transcriptional activation by promoting disassembly of transcriptional regulatory complexes (4).
Related PathwayNuclear Hormone ReceptorDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - p23 antibody [EPR3846]; All lanes : Anti-p23 antibody [EPR3846] at 1/10000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : Human spleen lysate.Lane 3 : Jurkat cell lysate.Lane 4 : HepG2 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP-labeled goat anti-rabbit at 1/2000 dilution.Predicted band size : 19 kDa.Observed band size : 23 kDa .
Immunocytochemistry/ Immunofluorescence - p23 antibody [EPR3846]; Immunofluorescent staining of HeLa cells, using TA307152 at a dilution of 1/100.


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