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Home Antibody All anti-PTEN antibodies

Anti-PTEN Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306223
  • Rabbit Polyclonal PTEN Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC424803) , 20ug
100ug $325 3-7 Days
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WB(1)
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Also for PTEN (NM_000314)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenPTEN antibody was raised against a 16 amino acid peptide from near the carboxy-terminus of human PTEN.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens phosphatase and tensin homolog (PTEN)
Alternative Name10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; TEP1
Database LinkNP_000305
FunctionPTEN (phosphatase and tensin homologue deleted on chromosome ten) is a dual-specificity phosphatase (with both protein and lipid phosphatase activity) first identified as a tumor suppressor gene. PTEN indirectly activates the AKT/PI3K pathway, an important signaling pathway for cell growth and proliferation by keeping levels of the second messenger PIP3 low, thereby preventing phosphoinositide-dependent kinase-1 (PDK-1) from phosphorylating and activating AKT. Expression of wild-type PTEN causes growth arrest in many cancer cell lines, but expression of a PTEN protein containing a mutation that blocks its lipid phosphatase activity failed to suppress growth of glioma cell lines suggesting that the tumor suppressive effect of PTEN is mediated solely by its lipid phosphatase activity. Other activities include the inhibition of insulin stimulated MAPK activation by blocking the insulin-receptor substrate (IRS)-1 phosphorylation and assembly of the IRS-1/Grb2/Sos complex.
Related Pathway
Focal Adhesion
Senescence and Autophagy

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WB Image
Western blot analysis of PTEN in PC-3 cell lysate with PTEN antibody at 1 µg/ml in either the (A) absence or (B) presence of blocking peptide.

 

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