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Anti-PTCH1 TRUEMAB Antibody clone 3c2
TrueMAB Antibodies - Made against Authentic Protein Antigens
Also for PTCH1 (NM_000264)
|Recombinant protein expressed in E.coli corresponding to amino acids 122-436 of human Patched1|
||WB: 1:500, IF (1:100)
|PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purified from mouse ascites fluids by affinity chromatography (Protein A or G Sepharose)
|Homo sapiens patched 1 (PTCH1), transcript variant 1b|
|BCNS; HPE7; NBCCS; PTC; PTC1; PTCH; PTCH11|
|This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.|
Hedgehog signaling pathway
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PTCH1(RC216999) (RC216999, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PTCH1.
Anti-Patched1 mouse monoclonal antibody (TA500122) immunofluorescent staining of HeLa cells transiently transfected by pCMV6-ENTRY PTCH1(RC201597)