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Anti-PTCH1 TRUEMAB Antibody Clone OTI3c2

TrueMAB™ Antibodies - Made against Authentic Protein Antigens


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA500122 anti-Patched1 (Patched) mouse monoclonal antibody, clone OTI3c2 (formerly 3c2) 100ul 325
In Stock
LC424834 PTCH1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF500122 Carrier-free (BSA/glycerol-free) Patched1 mouse monoclonal antibody, clone OTI3c2 (formerly 3c2) 100ug $450 8-10 Days
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Also for PTCH1 (NM_000264)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenRecombinant protein expressed in E.coli corresponding to amino acids 122-436 of human Patched1
Clone NameClone OTI3c2 IsotypeIgG2b
Species ReactivityHuman Concentration0.85 mg/ml
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:500, IF (1:100)
Predicted MW Explanation 160.4 kDa
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens patched 1 (PTCH1), transcript variant 1b
Alternative NameBCNS; HPE7; NBCCS; PTC; PTC1; PTCH; PTCH11
Database LinkNP_000255
Entrez Gene 5727 Human
FunctionThis gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.
Related PathwayES Cell Differentiation/IPSTransmembraneDruggable Genome Hedgehog signaling pathwayPathways in cancerBasal cell carcinoma

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PTCH1(RC216999) (RC216999, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PTCH1.

IF Image
Anti-Patched1 mouse monoclonal antibody (TA500122) immunofluorescent staining of HeLa cells transiently transfected by pCMV6-ENTRY PTCH1(RC201597)


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