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Also for PSMB8 (NM_004159)
|Recombinant fragment corresponding to a region within amino acids 52 and 276 of PSMB8 (Uniprot ID#P28062)|
|Human (Predicted: Rat, Dog, Pig, Xenopus laevis, Zebrafish, Bovine)
|WB, IHC, IF
||ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Dog (91%), Pig (94%), Rat (94%), Xenopus laevis (83%), Zebrafish (82%), Bovine (93%), Xenopus tropicalis (82%)
|Homo sapiens proteasome (prosome, macropain) subunit, beta type, 8 (PSMB8), transcript variant 1|
|ALDD; D6S216; D6S216E; JMP; LMP7; NKJO; PSMB5i; RING10|
Entrez Gene 5696 Human
Entrez Gene 24968 Rat
Entrez Gene 474865 Dog
|The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit. [provided by RefSeq]|
|ProteaseDruggable Genome Proteasome|
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Sample (30 ug of whole cell lysate). A: Raji. 12% SDS PAGE. TA308731 diluted at 1:1000.
PSMB8 antibody [N2C3] detects PSMB8 protein at cytosol and nucleus on mouse liver by immunohistochemical analysis. Sample: Paraffin-embedded mouse liver. PSMB8 antibody [N2C3] (TA308731) dilution: 1:250.
Immunohistochemical analysis of paraffin-embedded Cal27 Xenograft, using PSMB8(TA308731) antibody at 1:100 dilution.
Immunofluorescence analysis of paraformaldehyde-fixed A431, using PSMB8(TA308731) antibody at 1:200 dilution.