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Anti-PSMA7 TRUEMAB Antibody clone 5E3
TrueMAB Antibodies - Made against Authentic Protein Antigens
Also for PSMA7 (NM_002792)
|Full length human recombinant protein of human PSMA7 (NP_002783) produced in HEK293T cell.|
||WB 1:500, IHC 1:50, Flow 1:100
|PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purified from mouse ascites fluids by affinity chromatography (Protein A or G Sepharose)
|Homo sapiens proteasome (prosome, macropain) subunit, alpha type, 7 (PSMA7)|
|C6; HSPC; RC6-1; XAPC7|
|The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. This particular subunit has been shown to interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. In addition, this subunit is involved in regulating hepatitis virus C internal ribosome entry site (IRES) activity, an activity essential for viral replication. This core alpha subunit is also involved in regulating the hypoxia-inducible factor-1alpha, a transcription factor important for cellular responses to oxygen tension. Multiple isoforms of this subunit arising from alternative splicing may exist but alternative transcripts for only two isoforms have been defined. A pseudogene has been identified on chromosome 9. |
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PSMA7 (RC201169, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PSMA7.
HEK293T cells transfected with either pCMV6-ENTRY PSMA7(RC201169)(Red) or empty vector control plasmid(Blue) were immunostained with anti-PSMA7 mouse monoclonal(TA500690, Dilution 1:1,000), and then analyzed by flow cytometry.