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Also for PSMA6 (NM_002791)
|Recombinant fragment contain a sequence corresponding to a region within amino acids 1 and 234 of Proteasome 20S alpha 6 (Uniprot ID#P60900)|
|Human, Mouse (Predicted: Rat, Sheep, Rhesus Monkey, Chimpanzee, Bovine)
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Rat (100%), Sheep (100%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (100%)
|Homo sapiens proteasome (prosome, macropain) subunit, alpha type, 6 (PSMA6), transcript variant 1|
|IOTA; p27K; PROS27|
Entrez Gene 5687 Human
Entrez Gene 26443 Mouse
Entrez Gene 29673 Rat
Entrez Gene 699631 Monkey
|The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. A pseudogene has been identified on the Y chromosome. [provided by RefSeq]|
|ProteaseStem cell - PluripotencyDruggable Genome Proteasome|
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Sample(30 ug whole cell lysate). A:Hep G2 . 7.5% SDS PAGE. TA308942 diluted at 1:500
Sample (50 ug of whole cell lysate). A: Mouse brain. 12% SDS PAGE. TA308942 diluted at 1:1000.
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using 20S Proteasome alpha 6(TA308942) antibody at 1:200 dilution.