Home Antibody All anti-PRTFDC1 antibodies
Also for PRTFDC1 (NM_020200)
|PRTFDC1 antibody was raised against a 14 amino acid peptide from near the center of human PRTFDC1.|
|Human, Mouse, Rat
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens phosphoribosyl transferase domain containing 1 (PRTFDC1), transcript variant 1|
|Phosphoribosyl transferase domain containing 1 (PRTFDC1) is highly homologous to the hypoxanthine phosphoribosyltransferase (HPRT1) and may have arisen from a gene duplication event of a common ancestor gene. Recently, it was shown that CpG islands in the PRTFDC1 promoter could be hypermethylated in ovarian cancers and oral squamous-cell carcinomas (OSCC), leading to gene silencing. Restoration of PRTFDC1 expression in OSCC inhibited cell growth in colony-formation assays, while knockdown of PRTFDC1 expression in OSCC that expressed the gene promoted cell growth. These results suggest that PRTFDC1 can act as a tumor-suppressor gene. At least three isoforms of PRTFDC1 are known to exist.|
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Western blot analysis of PRTFDC1 in human brain tissue lysate with PRTFDC1 antibody at 1 µg/ml in the (A) absence and (B) presence of blocking peptide.