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Anti-PRKCG Antibody EPR2750
Also for PRKCG (NM_002739)
|A synthetic peptide corresponding to residues on the C-terminus in human PKC gamma was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; ICC: 1:50
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens protein kinase C, gamma (PRKCG)|
|PKC-gamma; PKCC; PKCG; SCA14|
|Members of the protein kinase C (PKC) family of serine/threonine kinases play a key role in regulating the differentiation and growth of diverse cell types. PKC gamma is activated by various secondary messengers such as calcium, diacylglycerol, phosphatidylserine, and phorbol ester. After activation by phorbol, it moves to the cytoplasm and regulates intracellular communication in epithelial cells. PKC gamma expression is specific to neurons in the brain and spinal cord, playing an important role in neurogenerative signal transduction (1). It is required for neuronal processes such as long term potentiation (LTP) and long term depression (LTD). PKC has three phosphorylation sites in its kinase domain, which are critical for full activation of PKC in response to various stimulants (2). Mutations in the PKC gamma gene have been linked to the neurodegenerative disorder spinocerebellar ataxia-14 (SCA14) (3).|
EGFR1 Signaling Pathway
MAPK signaling pathway
TGF Beta Signaling Pathway
Wnt Signaling Pathway
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Western blot - PKC gamma antibody [EPR2750]; All lanes : Anti-PKC gamma antibody [EPR2750] at 1/1000 dilution.Lane 1 : Human fetal brain cell lysate.Lane 2 : Human fetal cerebellum cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 78 kDa.