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Home Antibody All anti-PRF1 antibodies

Anti-PRF1 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA308615 Rabbit polyclonal antibody to Perforin 1 (perforin 1 (pore forming protein)) 100ul $325 3-7 Days
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WB(1)

OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 9 and 214 of Perforin 1 (Uniprot ID#P14222)
Clone Name IsotypeIgG
Species ReactivityHuman Concentration0.37mg/ml
Guaranteed Application *WB Suggested DilutionsWB:1:500-1:3000
Predicted MW Explanation 61kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.

Reference Data

Target NameHomo sapiens perforin 1 (pore forming protein) (PRF1), transcript variant 2
Alternative NameFLH2; HPLH2; P1; PFN1; PFP
Database LinkNP_001076585
Entrez Gene 5551 Human
FunctionThe protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq]
Related PathwayDruggable Genome Natural killer cell mediated cytotoxicityType I diabetes mellitusAutoimmune thyroid diseaseAllograft rejectionGraft-versus-host diseaseViral myocarditisMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Sample (30 ug of whole cell lysate). A: Hep G2 . 7.5% SDS PAGE. Perforin 1 antibody. TA308615 diluted at 1:1000.
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