Home Antibody All anti-PRDM1 antibodies
Also for PRDM1 (NM_001198)
|PEN2 antibody was raised against a 13 amino acid peptide from near the carboxy terminus of human PEN2.|
|Human, Mouse, Rat
||ELISA, WB: 0.5 - 1 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens PR domain containing 1, with ZNF domain (PRDM1), transcript variant 1|
Entrez Gene 639 Human
Entrez Gene 12142 Mouse
Entrez Gene 309871 Rat
|Blimp-1 was initially identified as a zinc finger-containing protein that drives the maturation of B lymphocytes into immunoglobulin-secreting cells. Together with X-box-binding protein 1 (XBP1), Blimp-1 is induced upon terminal differentiation of plasma cells. The transcriptional repressor activity of Blimp-1 has also been found to regulate T cell homeostasis and function, possibly by suppressing the expression of the cytokines IL-2 and interferon-gamma during T cell development. More recent experiments have suggested that Blimp-1 also plays a major role in the formation of primordial germ cells (PGC) in developing mammalian embryos. In these experiments, Blimp-1-deficient mutant mouse embryos form a cluster of PGC-like cells which fail to show the expected migration, proliferation, and repression of homeobox genes that normally accompany specification of primordial germ cells.|
|Transcription Factors |
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Western blot analysis of Blimp-1 in A549 cell lysate with Blimp-1 antibody at (A) 0.5 and (B) 1ug/mL.
Immunofluorescence of Blimp-1 in mouse lung tissue with Blimp-1 antibody at 20 ug/mL.