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Anti-PPP2CA Antibody YE351
Also for PPP2CA (NM_002715)
|A synthetic peptide corresponding to residues in N-terminus of human PP2A-alpha was used as immunogen. Predicted to cross-react with bovin and pig, based on sequence homology.|
||Lot dependent; please refer to CoA along with shipment
||WB: 1:500; IHC: 1:50-100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Protein A purified
|Homo sapiens protein phosphatase 2, catalytic subunit, alpha isozyme (PPP2CA)|
|PP2Ac; PP2CA; PP2Calpha; RP-C|
Entrez Gene 5515 Human
Entrez Gene 24672 Rat
|Protein phosphatase type 2A (PP2A) is a protein serine/threonine phosphatase that controls fundamental cellular processes, including transcription, translation, metabolism, cell growth, apoptosis, and varied other signal transduction pathways (1-3). PP2A is comprised of a core enzyme, which is made up of catalytic C and regulatory A (PR65) subunits, and a secondary regulatory B subunit. This B subunit contains four different protein families. In response to EGF or insulin, it has been shown that Src phosphorylates PP2A at Tyr307, thereby inactivating PP2A (4). |
|PhosphataseTranscription FactorsDruggable Genome Oocyte meiosisWnt signaling pathwayTGF-beta signaling pathwayTight junctionLong-term depression|
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Western blot - PP2A alpha antibody [YE351]; All lanes : Anti-PP2A alpha antibody [YE351] at 1/500 dilution.Lane 1 : A431 cell lysate.Lane 2 : NIH 3T3 cell lysate.Predicted band size : 36 kDa.Observed band size : 37 kDa .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - PP2A alpha antibody [YE351]; TA300445 at a 1/50 dilution staining in human PP2A alpha catalitic subunit prostate carcinoma, using Immunohistochemistry, Paraffin Embedded Tissue.