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Anti-PON1 Antibody EPR2892
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Also for PON1 (NM_000446)
|A synthetic peptide corresponding to residues near the N-terminus in human PON 1 was used as an immunogen.|
||IHC: 1: 100 - 250, IP: 1 : 10 - 100, WB: 1 : 1,000 - 10,000,
|Store at -20 C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.|
|Homo sapiens paraoxonase 1 (PON1)|
|ESA; MVCD5; PON|
|Paraoxonase 1 (PON 1) is an esterase and lactonase that is synthesized in the liver and secreted into blood, associated exclusively with high density lipoproteins (HDL) (1, 3). It hydrolyzes the toxic oxon metabolites of several organophosphorous insecticides and nerve agents (2). This protein has been implicated in protection from atherosclerosis (2). PON 1 possesses both antioxidant and anti-inflammatory properties (1, 3). Protecting LDL and HDL from lipid peroxidation, PON 1 degrades specific oxidized cholesteryl esters and oxidized phospholipids contained in lipoproteins (1, 3, 4).|
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Western blot analysis on (A) human plasma cell and (B) ovary cancer lysates using anti-PON 1 RabMAb .
Immunohistochemical staining of paraffin-embedded human liver tissue using anti-PON 1 RabMAb .