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Home Antibody All anti-POMC antibodies

Anti-POMC TRUEMAB Antibody Clone 1F3

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA506611
  • POMC mouse monoclonal antibody,clone 1F3
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC422129) , 20ug Explanation
100ul 325 In Stock
CF506611
  • Carrier-free (BSA/glycerol-free) POMC mouse monoclonal antibody,clone 1F3
100ug $450 8-10 Days
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WB(1)
IHC(2)
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Also for POMC (NM_001035256)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenFull length human recombinant protein of human POMC(NP_001030333) produced in HEK293T cell.
Clone NameClone 1F3 IsotypeIgG1
Species ReactivityHuman Concentration1.00mg/ml
Guaranteed Application *WB, IHC Suggested Dilutions WB 1:400~4000, IHC 1:150,
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens proopiomelanocortin (POMC), transcript variant 1
Alternative NameACTH; CLIP; LPH; MSH; NPP; POC
Database LinkNP_001030333
FunctionThis gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].
Related Pathway
Melanogenesis
Signaling by GPCR

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY POMC (RC215351, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-POMC.
IHC Image
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-POMC mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA506611)
IHC Image
Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-POMC mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA506611)

 

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