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Anti-PLN PHOSPHO Antibody EPR1911
|A phospho specific peptide corresponding to residues surrounding Serine 16 of human Phospholamban was used as an immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
||IP: 1:50, WB: 1:200,000 - 500,000,
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Does not react with Rat
|Homo sapiens phospholamban (PLN)|
|CMD1P; CMH18; PLB|
|Phospholamban is a major substrate for the cAMP-dependent kinase in cardiac muscle. It regulates the activity of the calcium pump of cardiac sarcoplasmic reticulum. It inhibits cardiac muscle sarcoplasmic reticulum Ca2+-ATPase in the unphosphoyrlated state, but inhibition is relieved upon phosphorylation of the protein (1). Beta-adrenergic stimulation results in PLB phosphorylation by both cAMP-dependent protein kinase at Serine 16 and calcium/calmodulin-dependent protein kinase at Serine 17 (2). Phospholamban is expressed in slow twitch skeletal muscle and some smooth muscle as well as in cardiac muscle (1). |
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Western blot - Phospholamban (phospho S16) antibody [EPR1911]; All lanes : Anti-Phospholamban (phospho S16) antibody [EPR1911] at 1/200000 dilution.Lane 1 : Fetal heart lysate (untreated).Lane 2 : Fetal heart lysate (treated with LP).Lysates/proteins at 10 µg per lane.Secondary.HRP labelled Goat anti-Rabbit antibody at 1/2000 dilution.Predicted band size : 6 kDa.