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Anti-PLCG2 PHOSPHO Antibody EP1405Y
Also for PLCG2 (NM_002661)
|A phospho specific peptide corresponding to residues surrounding tyrosine 1197 of human PLC?II was used as an immunogen. This antibody detects PLC?II phosphorylated on tyrosine 1197.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:2000 - 1:20000; IP: 1:40; ICC: 1:100 - 1:250
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt or IHC-P.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for Flow Cyt or IHC-P.
|Homo sapiens phospholipase C, gamma 2 (phosphatidylinositol-specific) (PLCG2)|
|APLAID; FCAS3; RP11-510J16.3|
|Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups. A number of these enzymes have specificity for phosphoinositides. Of the phosphoinositide-specific phospholipase C enzymes, C-beta is regulated by heterotrimeric G protein-coupled receptors, while the closely related C-gamma-1 (PLCG1; MIM 172420) and C-gamma-2 enzymes are controlled by receptor tyrosine kinases. The C-gamma-1 and C-gamma-2 enzymes are composed of phospholipase domains that flank regions of homology to noncatalytic domains of the SRC oncogene product, SH2 and SH3.[supplied by OMIM]. |
EGFR1 Signaling Pathway
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Western blot - PLCG 2 (phospho Y1197) antibody [EP1405Y]; All lanes : Anti-PLCG 2 (phospho Y1197) antibody [EP1405Y] at 1/20000 dilution.Lane 1 : Raji cell lysates un-treated.Lane 2 : Raji cell lysates treated with pervanadate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 148 kDa.Observed band size : 150 kDa .