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Home Antibody All anti-PLCG1 antibodies

Anti-PLCG1 PHOSPHO Antibody

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SKU Description Amount Price Availability*  
TA322973 Anti-PLCG1 (phospho-Tyr771) Rabbit Polyclonal Antibody 100ul $325 2-3 Weeks
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WB(1)
IF(1)
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Also for PLCG1 (NM_002660)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenPeptide sequence around phosphorylation site of tyrosine 771 (P-D-Y(p)-G-A) derived from Human PLC-?1.
Clone Name IsotypeIgG
Species ReactivityHuman; Mouse; Rat Concentration1mg/ml
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:500-1000, IF: 1:100-200
Predicted MW Explanation 155kDa
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens phospholipase C, gamma 1 (PLCG1), transcript variant 1
Alternative NameNCKAP3; PLC-II; PLC1; PLC148; PLCgamma1
Database LinkNP_002651
Entrez Gene 5335 Human
Entrez Gene 18803 Mouse
Entrez Gene 25738 Rat
FunctionThe protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.
Related PathwayDruggable Genome Inositol phosphate metabolismMetabolic pathwaysErbB signaling pathwayCalcium signaling pathwayPhosphatidylinositol signaling systemVEGF signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Predicted band size: 155 kDa . Positive control: NIH/3T3 cells untreated or treated with serum lysate. Recommended dilution: 1/ 500-1000. (Gel: 8%SDS-PAGE Lane1: NIH/3T3 cells untreated with serum lysate Lane2: NIH/3T3 cells treated with serum lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)
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Predicted cell location: Cell projection . Positive control: Hela cells. Recommended dilution: 1/ 100-200.The image is immunofluorescence of methanol-fixed Hela cells using PLCG1 (phospho-Tyr771) antibody at dilution 1/100. (Original magnification: ×200)
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