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Anti-PLCG1 PHOSPHO Antibody EPR2611Y
Also for PLCG1 (NM_002660)
|A phospho specific peptide corresponding to residues surrounding tyrosine 783 of human PLCgamma1 was used as an immunogen. This antibody detects PLCgamma1 phosphorylated on tyrosine 783.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:5000 - 1:10000; ICC: 1:100 - 1:250
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt,IHC-P or IP.|
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens phospholipase C, gamma 1 (PLCG1), transcript variant 1|
|NCKAP3; PLC-II; PLC1; PLC148; PLCgamma1|
|The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. |
EGFR1 Signaling Pathway
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Western blot - Anti-Phospholipase C gamma 1 (phospho Y783) antibody [EPR2611Y]; All lanes : Anti-Phospholipase C gamma 1 (phospho Y783) antibody [EPR2611Y] at 1/10000 dilution.Lane 1 : Jurkat cell lysate untreated.Lane 2 : Jurkat cell lysate treated with Pervanadate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 148 kDa.Observed band size : 150 kDa .