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Home Antibody All anti-PLCG1 antibodies

Anti-PLCG1 PHOSPHO Antibody EPR2611Y

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SKU Description Amount Price Availability*  
TA303646
  • Rabbit monoclonal antibody against PLC ? 1 Phospho (pY783) (EPR2611Y ) (phospho-specific)
100ul $325 3-7 Days
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WB(1)
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Also for PLCG1 (NM_002660)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding tyrosine 783 of human PLCgamma1 was used as an immunogen. This antibody detects PLCgamma1 phosphorylated on tyrosine 783.
Clone NameEPR2611Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:5000 - 1:10000; ICC: 1:100 - 1:250
BufferpH: 7.40Preservative: 0.01% Sodium azide; Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens phospholipase C, gamma 1 (PLCG1), transcript variant 1
Alternative NameNCKAP3; PLC-II; PLC1; PLC148; PLCgamma1
Database LinkNP_002651
Entrez Gene 5335 Human
FunctionThe protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Related PathwayDruggable Genome Inositol phosphate metabolismMetabolic pathwaysErbB signaling pathwayCalcium signaling pathwayPhosphatidylinositol signaling systemVEGF signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-Phospholipase C gamma 1 (phospho Y783) antibody [EPR2611Y]; All lanes : Anti-Phospholipase C gamma 1 (phospho Y783) antibody [EPR2611Y] at 1/10000 dilution.Lane 1 : Jurkat cell lysate untreated.Lane 2 : Jurkat cell lysate treated with Pervanadate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 148 kDa.Observed band size : 150 kDa .
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