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Home Antibody All anti-PLCG1 antibodies

Anti-PLCG1 PHOSPHO Antibody EPR2611Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA303646
  • Rabbit monoclonal antibody against PLC ? 1 Phospho (pY783) (EPR2611Y ) (phospho-specific)
100ul 325 3-7 Days
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WB(1)
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Also for PLCG1 (NM_002660)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding tyrosine 783 of human PLCgamma1 was used as an immunogen. This antibody detects PLCgamma1 phosphorylated on tyrosine 783.
Clone NameEPR2611Y IsotypeTissue culture supernatant
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:5000 - 1:10000; ICC: 1:100 - 1:250
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,IHC-P or IP.
Purification pH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens phospholipase C, gamma 1 (PLCG1), transcript variant 1
Alternative NameNCKAP3; PLC-II; PLC1; PLC148; PLCgamma1
Database LinkNP_002651
FunctionThe protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Related Pathway
EGFR1 Signaling Pathway
Hemostasis

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WB Image
Western blot - Anti-Phospholipase C gamma 1 (phospho Y783) antibody [EPR2611Y]; All lanes : Anti-Phospholipase C gamma 1 (phospho Y783) antibody [EPR2611Y] at 1/10000 dilution.Lane 1 : Jurkat cell lysate untreated.Lane 2 : Jurkat cell lysate treated with Pervanadate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 148 kDa.Observed band size : 150 kDa .

 

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