Home Antibody All anti-PLAU antibodies
Also for PLAU (NM_002658)
| Peptide with sequence C-HFLPWIRSHTKEEN, from the C Terminus of the protein sequence according to NP_002649.1.|
|Test: Human. Expected from seq similarity: Human
||ELISA: 1:8,000. WB: 0.3-1.0µg/ml.
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
|Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
|Homo sapiens plasminogen activator, urokinase (PLAU), transcript variant 1|
|ATF; BDPLT5; QPD; u-PA; UPA; URK|
Entrez Gene 5328 Human
|This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. |
|ES Cell Differentiation/IPSProteaseDruggable Genome Complement and coagulation cascades|
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TA302671 (0.3µg/ml) staining of 293 lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.