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Anti-PKLR TRUEMAB Antibody Clone OTI1H4

TrueMAB™ Antibodies - Made against Authentic Protein Antigens


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA501413 PKLR mouse monoclonal antibody, clone OTI1H4 (formerly 1H4) 100ul 325
In Stock
LC400113 PKLR HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF501413 Carrier-free (BSA/glycerol-free) PKLR mouse monoclonal antibody, clone OTI1H4 (formerly 1H4) 100ug $450 3-4 weeks
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OriGene Data

ImmunogenFull length human recombinant protein of human PKLR (NP_000289) produced in HEK293T cell.
Clone NameClone OTI1H4 IsotypeIgG2a
Species ReactivityHuman Concentration0.57 mg/ml
Guaranteed Application *WB, IF, FC Suggested DilutionsWB 1:2000, IF 1:100, FLOW 1:100
Predicted MW Explanation 61.6 kDa
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens pyruvate kinase, liver and RBC (PKLR), transcript variant 1
Alternative NamePK1; PKL; PKR; PKRL; RPK
Database LinkNP_000289
Entrez Gene 5313 Human
FunctionThe protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Related PathwayDruggable Genome Glycolysis / GluconeogenesisPurine metabolismPyruvate metabolismMetabolic pathwaysInsulin signaling pathwayType II diabetes mellitusMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PKLR (RC206455, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PKLR.
Anti-PKLR mouse monoclonal antibody (TA501413) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PKLR(RC206455).
HEK293T cells transfected with either RC206455 overexpress plasmid(Red) or empty vector control plasmid(Blue) were immunostained by anti-PKLR antibody(TA501413), and then analyzed by flow cytometry.
Flow cytometric Analysis of Jurkat cells, using anti-PKLR antibody(TA501413),(Red), compared to a nonspecific negative control antibody(TA50011),(Blue).


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