OriGene Technologies, Inc.
Search:    
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
 
Home Antibody All anti-PIN1 antibodies

Anti-PIN1 PHOSPHO Antibody EP1480Y

div

Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301037
  • Rabbit Monoclonal Antibody against PIN1 (Clone EP1480Y) (Phospho-specific)
100ul 325 3-7 Days
Add to Shopping Cart
WB(1)
spacer
Also for PIN1 (NM_006221)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surround Serine 16 of human Pin1 was used as an immunogen. This antibody detects Pin1 phosphorylated at Serine 16.
Clone NameEP1480Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:500; ICC: 1: 100~250
Predicted MW Explanation 18 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (PIN1), transcript variant 1
Alternative NameDOD; UBL5
Database LinkNP_006212
Entrez Gene 5300 Human
FunctionHuman human rotamase or peptidyl-prolyl cis-trans isomerase Pin1(PPIase) is important in protein folding, assembly and/or transport. Pin1 is nuclear PPIase containing a WW protein interaction domain, and is structurally and functionally related to Ess1/Ptf1, an essential protein in budding yeast. PPIase activity is necessary for Pin1 function in yeast. Depletion of Pin1 from yeast or HeLa cells induces mitotic arrest, whereas HeLa cells overexpressing Pin1 arrest in the G2 phase of the cell cycle. Pin1 is thus an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity (1). Pin1 is a conserved mitotic regulator essential for the G2/M transition of the eukaryotic cell cycle. Pin1 displays a preference for an acidic residue N-terminal to the isomerized proline bond due to interaction of this acidic side chain with a basic cluster. This raises the possibility of phosphorylation-mediated control of Pin1-substrate interactions in cell cycle regulation (2).
Related PathwayDruggable Genome RIG-I-like receptor signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Pin1 (phospho S16) antibody [EP1480Y]; All lanes : Anti-Pin1 (phospho S16) antibody [EP1480Y] at 1/500 dilution.Lane 1 : HeLa cell lysate (untreated).Lane 2 : HeLa cell lysate (treated with FBS + Calyculin A).Lysates/proteins at 10 ug per lane.Secondary.Goat anti-Rabbit HRP conjugated at 1/2000 dilution.Predicted band size : 18 kDa.Observed band size : 18 kDa.

 

spacer
Inc 5000 Healthcare Company Copyright © 2014 OriGene Technologies, Inc. All Rights Reserved. Legal Notices.
9620 Medical Center Dr., Suite 200, Rockville, MD 20850 • 1.888.267.4436

Reproduction of any materials from this website is strictly forbidden without permission.

All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title