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Anti-PIAS1 Antibody EPR2581Y


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against PIAS1 (C-term) (clone EPR2841Y )
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402513) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the C-terminus of human PIAS1 was used as an immunogen.
Clone NameEPR2581Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsFC: 1:10 - 1:100; WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250
Predicted MW Explanation 72 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens protein inhibitor of activated STAT, 1 (PIAS1)
Alternative NameDDXBP1; GBP; GU/RH-II; ZMIZ3
Database LinkNP_057250
Entrez Gene 8554 Human
Entrez Gene 56469 Mouse
Entrez Gene 300772 Rat
FunctionPIAS1 (protein inhibitor of activated STAT) proteins blocks the DNA binding activity of Stat1 and inhibits Stat1-mediated gene activation in response to cytokine stimulation (1). PIAS1 also plays a crucial role as a transcriptional coregulator in the p53 pathway and the steroid hormone signaling pathway and functions as an E3 type small ubiquitin-like modifier (SUMO) ligas, stabilizing the interaction between UBEZ1 and the substrate, and as a SUMO-tethering factor. It is expressed in numerous tissues with highest level in testes.
Related PathwayTranscription FactorsDruggable Genome Ubiquitin mediated proteolysisJak-STAT signaling pathwayPathways in cancerSmall cell lung cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - PIAS1 antibody [EPR2581Y] - Carboxyterminal end; All lanes : Anti-PIAS3 + PIAS1 + PIAS2 [EPR2581Y] antibody at 1/50000 dilution.Lane 1 : Daudi cell lysate.Lane 2 : 293 cell lysate.Lane 3 : Jurkat cell lysate.Lane 4 : SW40 cell lysate.Lane 5 : HepG2 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 72 kDa.Observed band size : 78 kDa .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - PIAS1 antibody [EPR2581Y] - Carboxyterminal end; TA307090, at a 1/100 dilution, staining PIAS1 in paraffin embedded human tonsil tissue by Immunohistochemistry.


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