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Home Antibody All anti-PHOX2A antibodies

Anti-PHOX2A Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319069
  • Rabbit polyclonal anti-PHOX2A antibody (CT)
100ug 379 3-7 Days
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WB(1)
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Also for PHOX2A (NM_005169)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenPHOX2A antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human PHOX2A.
Clone Name IsotypeRabbit IgG1
Species ReactivityHuman, Mouse, Rat Concentration1 mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 1ug/ml, IHC: 2.5ug/ml, ELISA
Buffer100 µg (1 mg/ml) in 1X PBS containing 0.02 % sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens paired-like homeobox 2a (PHOX2A)
Alternative NameARIX; CFEOM2; FEOM2; NCAM2; PMX2A
Database LinkNP_005160
Entrez Gene 401 Human
Entrez Gene 11859 Mouse
Entrez Gene 116648 Rat
FunctionPHOX2A and PHOX2B (Paired mesoderm homeobox protein) are closely related, paired-homeodomain transcription factors that function as determinants of the noradrenergic phenotype during embryogenesis. PHOX2 proteins are crucial for the regulation of endogenous hydroxylases in neural crest cells and promote sympathetic neuron generation. Human PHOX2B contains one DNA binding homeobox domain and is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain. In contrast, PHOX2A controls only the differentiation of the main noradrenergic center of the brain. Regulation of PHOX2 may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons.
Related PathwayTranscription Factors

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of PHOX2A in rat brain tissue lysate with PHOX2A antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.

 

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