Home Antibody All anti-PHOX2A antibodies
Also for PHOX2A (NM_005169)
|PHOX2A antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human PHOX2A.|
|Human, Mouse, Rat
||WB: 1ug/ml, IHC: 2.5ug/ml, ELISA
|100 µg (1 mg/ml) in 1X PBS containing 0.02 % sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens paired-like homeobox 2a (PHOX2A)|
|ARIX; CFEOM2; FEOM2; NCAM2; PMX2A|
|PHOX2A and PHOX2B (Paired mesoderm homeobox protein) are closely related, paired-homeodomain transcription factors that function as determinants of the noradrenergic phenotype during embryogenesis. PHOX2 proteins are crucial for the regulation of endogenous hydroxylases in neural crest cells and promote sympathetic neuron generation. Human PHOX2B contains one DNA binding homeobox domain and is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain. In contrast, PHOX2A controls only the differentiation of the main noradrenergic center of the brain. Regulation of PHOX2 may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons.|
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Western blot analysis of PHOX2A in rat brain tissue lysate with PHOX2A antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.