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Anti-PDK2 Antibody EPR1948Y


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal Antibody against PDK2 (Clone EPR1948Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400923) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human PDK2 was used as an immunogen.
Clone NameEPR1948Y IsotypeIgG
Species ReactivityMouse, Rat, Human, Pig ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500; IHC: 1: 100~250; ICC: 1: 100~250; FC: 1:60; IP: 1:30
Predicted MW Explanation 46 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens pyruvate dehydrogenase kinase, isozyme 2 (PDK2), transcript variant 1
Alternative NamePDHK2; PDKII
Database LinkNP_002602
Entrez Gene 5164 Human
Entrez Gene 18604 Mouse
Entrez Gene 81530 Rat
FunctionA member of Pyruvate dehydrogenase kinase (PDK1, 2, 3, and 4), PDK2 is a serine kinase which is involved in the regulation of mammalian glucose metabolism. During aerobic energy metabolism, mitochondrial pyruvate dehydrogeanse complex (PDC) catalyzes decarboxylation of pyruvate to form acetyl-CoA (1). PDK2 inhibits PDC thru phosphorylation of the E1 alpha subunit of PDC and inactivates the complex (2). Highly expressed in heart and skeletal muscles, PDK2 is also responsible for the phosphorylation of Akt at Ser473, which leads to phosphorylation by PDK1 on Thr308 on Akt and full Akt activation (3).
Related PathwayProtein KinaseDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - PDK2 antibody [EPR1948Y]; All lanes : Anti-PDK2 [EPR1948Y] antibody at 1/2000 dilution.Lane 1 : human heart tissue lysate.Lane 2 : mouse heart tissue lysate.Lane 3 : rat tissue lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 46 kDa.Observed band size : 46 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - PDK2 antibody [EPR1948Y]; TA301140 at 1/100-1/250 dilution staining PDK2 in human muscle tissue sections.


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