Homo sapiens platelet-derived growth factor receptor, beta polypeptide (PDGFRB)
CD140B; IBGC4; JTK12; PDGFR; PDGFR-1; PDGFR1
A phospho specific peptide corresponding to residues surrounding tyrosine 771 of human PDGF Receptor beta was used as an immunogen. This antibody only detects PDGF Receptor beta phosphorylated at tyrosine 771.
Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Human platelet derived growth factor (PDGF) receptor is a receptor tyrosine kinase whose activity induces various signaling cascades leading to cell growth and proliferation. The two major isoforms that exist are PDGF Receptor beta and PDGF Receptor alpha. PDGF Receptor beta can only bind to two PDGF isoforms, PDGF-beta and PDGF-delta (1, 2). Upon ligand binding, the receptor undergoes dimerization, resulting in autophosphorylation to allow activation of cytoplasmic SH2 domain-containing signal transduction molecules such as PI kinase, Grb2, Src, etc. (3). One autophosphorylation site in PDGF Receptor beta, Tyrosine 771, is able to mediate the specific binding of the Shc SH2 domain (4). A chromosomal aberration involving the PDGF Receptor beta is found in a form of chronic myelomonocytic leukemia (5).
Cytokine-cytokine receptor interaction
MAPK signaling pathway
* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.