Home Antibody All anti-PCMT1 antibodies
Also for PCMT1 (NM_005389)
|Recombinant protein fragment contain a sequence corresponding to a region within amino acids 10 and 227 of PCMT1|
|WB, IHC, IF
||ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Homo sapiens protein-L-isoaspartate (D-aspartate) O-methyltransferase (PCMT1), transcript variant 1|
Entrez Gene 5110 Human
|Three classes of protein carboxyl methyltransferases, distinguished by their methyl-acceptor substrate specificity, have been found in prokaryotic and eukaryotic cells. The type II enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the free carboxyl groups of D-aspartyl and L-isoaspartyl residues. These methyl-accepting residues result from the spontaneous deamidation, isomerization, and racemization of normal L-aspartyl and L-asparaginyl residues and represent sites of covalent damage to aging proteins PCMT1 (EC 188.8.131.52) is a protein repair enzyme that initiates the conversion of abnormal D-aspartyl and L-isoaspartyl residues to the normal L-aspartyl form.[supplied by OMIM]|
|Druggable Genome |
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Sample (30 ug of whole cell lysate). A: 293T. 12% SDS PAGE. TA308667 diluted at 1:1000.
Immunohistochemical analysis of paraffin-embedded U87 xenograft, using PCMT1(TA308667) antibody at 1:500 dilution.
Immunofluorescence analysis of methanol-fixed A431, using PCMT1(TA308667) antibody at 1:200 dilution.