Home Antibody All anti-PCBP2 antibodies
Also for PCBP2 (NM_005016)
|Synthetic peptide corresponding to a region within amino acids 302 and 365 of PCBP2 (Uniprot ID#Q15366)|
|Human (Predicted: Mouse, Rat, Xenopus laevis, Pig, Bovine)
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Mouse (100%), Rat (100%), Xenopus laevis (93%), Pig (100%), Bovine (100%)
|Homo sapiens poly(rC) binding protein 2 (PCBP2), transcript variant 1|
|hnRNP-E2; HNRNPE2; HNRPE2|
Entrez Gene 5094 Human
Entrez Gene 18521 Mouse
Entrez Gene 363005 Rat
|The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
Sample (30 ug of whole cell lysate). A: Hep G2 . 10% SDS PAGE. TA308000 diluted at 1:500
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using PCBP2(TA308000) antibody at 1:200 dilution.