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Anti-PAWR Antibody EPR3991
Also for PAWR (NM_002583)
|A synthetic peptide corresponding to residues in human PAR4 was used as an immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
||IP: 1 : 10 - 100, WB: 1:10,000-50,000,
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Does not react with Rat
|Homo sapiens PRKC, apoptosis, WT1, regulator (PAWR)|
|Prostate apoptosis response protein (PAR4) is a proapoptotic protein with intracellular functions in the cytoplasm and nucleus, capable of suppressing tumors (1). Extracellular PAR4 induces apoptosis by binding to the stress response protein, glucose-regulated protein-78 (GRP78), via an extrinsic pathway (1). PAR4 contains leucine zipper and death domains that are upregulated in prostate cancer cells and hippocampal neurons induced to undergo apoptosis (2). Alzheimer’s and Parkinson’s diseases are both targets for PAR-4 in treatments that block its expression, preventing neuronal cell death (3). In Parkinson’s disease, the death of dopaminergic neurons follows a degenerative pathway that circumvents the apoptotic induction of PAR-4 (4). An isoform of PAR-4, PAR-4/p33, prevents apoptosis in neural stem cells and does not activate caspase 3 (5).|
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Western blot - PAR4 antibody [EPR3991]; All lanes : Anti-PAR4 antibody [EPR3991] at 1/10000 dilution.Lane 1 : LNCap cell lysate.Lane 2 : Jurkat cell lysate.Lane 3 : A549 cell lysate.Lane 4 : HeLa cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 37 kDa.