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Home Antibody All anti-PAWR antibodies

Anti-PAWR Antibody EPR3991

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307434
  • Rabbit monoclonal antibody against PAR4(clone EPR3991)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC419234) , 20ug
100ul 325 3-7 Days
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WB(1)
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Also for PAWR (NM_002583)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human PAR4 was used as an immunogen.
Clone NameEPR3991 IsotypeIgG
Species ReactivityHuman, Mouse Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsIP: 1 : 10 - 100, WB: 1:10,000-50,000,
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Rat

Reference Data

Target NameHomo sapiens PRKC, apoptosis, WT1, regulator (PAWR)
Alternative NamePar-4; PAR4
Database LinkNP_002574
FunctionProstate apoptosis response protein (PAR4) is a proapoptotic protein with intracellular functions in the cytoplasm and nucleus, capable of suppressing tumors (1). Extracellular PAR4 induces apoptosis by binding to the stress response protein, glucose-regulated protein-78 (GRP78), via an extrinsic pathway (1). PAR4 contains leucine zipper and death domains that are upregulated in prostate cancer cells and hippocampal neurons induced to undergo apoptosis (2). Alzheimer’s and Parkinson’s diseases are both targets for PAR-4 in treatments that block its expression, preventing neuronal cell death (3). In Parkinson’s disease, the death of dopaminergic neurons follows a degenerative pathway that circumvents the apoptotic induction of PAR-4 (4). An isoform of PAR-4, PAR-4/p33, prevents apoptosis in neural stem cells and does not activate caspase 3 (5).
Related Pathway

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WB Image
Western blot - PAR4 antibody [EPR3991]; All lanes : Anti-PAR4 antibody [EPR3991] at 1/10000 dilution.Lane 1 : LNCap cell lysate.Lane 2 : Jurkat cell lysate.Lane 3 : A549 cell lysate.Lane 4 : HeLa cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 37 kDa.</title><style>.an6q{position:absolute;clip:rect(487px,auto,auto,487px);}</style><div class=an6q>According to your current <a href=http://paydayloansforsure.com >need cash now</a> you really look at.</div>

 

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