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Anti-PARK2 PHOSPHO Antibody
Also for PARK2 (NM_004562)
|Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser378 conjugated to KLH|
||Lot dependent; please refer to CoA along with shipment
|100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. |
|Homo sapiens parkin RBR E3 ubiquitin protein ligase (PARK2), transcript variant 1|
|AR-JP; LPRS2; PDJ; PRKN|
Entrez Gene 5071 Human
|The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq]. |
| Ubiquitin mediated proteolysisParkinson's disease|
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Western blot of HEK293 cells transfected with Parkin WT (Phospho) and Parkin S378 mutant (non-phospho) showing the phospho-specific immunolabeling of the ~ 52 k parkin protein. The immunolabeling is absent in the parkin S378 mutant.