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Home Antibody All anti-ORAI1 antibodies

Anti-ORAI1 Antibody 6D11A11

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA320060
  • Mouse ORAI1 Monoclonal Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC403208) , 20ug Explanation
100ug 325 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenMouse monoclonal ORAI1 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human ORAI1.
Clone Name6D11A11 IsotypeIgG2b
Species ReactivityHuman, Mouse, Rat Concentration1mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsELISA, WB: 1 - 2 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
BufferORAI1 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Purification ORAI1 Monoclonal Antibody is immunoaffinity chromotography purified IgG.

Reference Data

Target NameHomo sapiens ORAI calcium release-activated calcium modulator 1 (ORAI1)
Alternative NameCRACM1; IMD9; ORAT1; TAM2; TMEM142A
Database LinkNP_116179
Entrez Gene 84876 Human
Entrez Gene 109305 Mouse
Entrez Gene 304496 Rat
FunctionORAI1 Monoclonal Antibody: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one fo rm of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE. This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of ORAI1 in human spleen tissue lysate with ORAI1 antibody at (A) 1 and (B) 2 ug/mL.
IHC Image
Immunohistochemistry of ORAI1 in human spleen tissue with ORAI1 antibody at 2.5 ug/mL.

 

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