Read Promotion Error: could not connect to redis Instance at 127.0.0.1:6912 Anti-ORAI1 Antibody, - OriGene
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Anti-ORAI1 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA306452 Rabbit Polyclonal ORAI1 Antibody 100ug In Stock
LC403208 ORAI1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(1)

OriGene Data

ImmunogenORAI1 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human ORAI1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens ORAI calcium release-activated calcium modulator 1 (ORAI1)
Alternative NameCRACM1; IMD9; ORAT1; TAM2; TMEM142A
Database LinkNP_116179
Entrez Gene 84876 Human
Entrez Gene 109305 Mouse
Entrez Gene 304496 Rat
FunctionAntigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE. This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.
Related PathwayTransmembrane

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of ORAI1 in human ovary tissue lysate with ORAI1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
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Immunohistochemistry of ORAI1 in human spleen tissue with ORAI1 antibody at 2.5 ug/ml.
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