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 Home All anti-ORAI1 antibodies

Anti-ORAI1 Antibody

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SKU Description Amount Price Availability*  
TA306452
  • Rabbit Polyclonal ORAI1 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC403208) , 20ug
 100ug $325 In Stock
TA802519S
  • Purified GAPDH mouse monoclonal antibody (Loading control), clone 2D9
 30ul
$100
$50*		 In Stock
Add to Shopping Cart
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
WB(1)
IHC(1)

OriGene Data

ImmunogenORAI1 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human ORAI1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column (Protein A or G Sepharose)

Reference Data

Target NameHomo sapiens ORAI calcium release-activated calcium modulator 1 (ORAI1)
Alternative NameCRACM1; ORAT1; TMEM142A
Database LinkNP_116179
FunctionAntigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE. This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.
Related Pathway

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WB Image
Western blot analysis of ORAI1 in human ovary tissue lysate with ORAI1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
IHC Image
Immunohistochemistry of ORAI1 in human spleen tissue with ORAI1 antibody at 2.5 ug/ml.

 

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