Home Antibody All anti-ORAI1 antibodies
Also for ORAI1 (NM_032790)
|ORAI1 antibody was raised against a 18 amino acid peptide from near the amino terminus of human ORAI1.|
||Lot dependent; please refer to CoA along with shipment
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens ORAI calcium release-activated calcium modulator 1 (ORAI1)|
|CRACM1; IMD9; ORAT1; TAM2; TMEM142A|
Entrez Gene 84876 Human
Entrez Gene 109305 Mouse
|Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE. This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.|
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Western blot analysis of ORAI1 in human ovary tissue lysate with ORAI1 antibody at 1 ug/ml in the (A) absence or (B) presence of blocking peptide.
Immunohistochemistry of ORAI1 in human spleen tissue with ORAI1 antibody at 10 ug/ml.