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Home Antibody All anti-NTRK2 antibodies

Anti-NTRK2 Antibody EPR1294

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA307647 Rabbit monoclonal antibody against Trk B(clone EPR1294) 100ul $325 In Stock
LC400391 NTRK2 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(4)
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Also for NTRK2 (NM_001007097)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Trk B was used as an immunogen.
Clone NameEPR1294 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250
BufferpH: 7.40Preservative: 0.01% Sodium azide; Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt or ICC.

Reference Data

Target NameHomo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant b
Alternative NameGP145-TrkB; trk-B; TRKB
Database LinkNP_001007098
Entrez Gene 4915 Human
FunctionNeurotrophins and their receptors play an important role in regulating development of both the central and the peripheral nervous systems (1). The binding of neurotrophin ligands to their respective Trk cellular receptors initiates intracellular signals essential for the growth and survival of neurons. The site of neurotrophin binding has been located to the fifth extracellular domain of the Trk receptor, with this region regulating both the affinity and specificity of the receptor: neurotrophin interaction (2). The Trk B receptor tyrosine kinase and its ligand, BDNF, have an essential role in certain forms of synaptic plasticity. Results provide evidence that Trk B mediates hippocampal plasticity via recruitment of PLC gamma, and by subsequent phosphorylation of CaMKIV (3). Also, Trk B has been found to be essential to the development of GABAergic neurons and the regulation of synapse formation in addition to its role in the development of axon terminals (4).
Related PathwayProtein KinaseTransmembraneDruggable Genome MAPK signaling pathwayNeurotrophin signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-TrkB antibody [EPR1294]; All lanes : Anti-TrkB antibody [EPR1294] at 1/1000 dilution.Lane 1 : Fetal brain lysate.Lane 2 : Human hippocampus lysate.Lane 3 : Human cerebellum lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 92 kDa.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TrkB antibody [EPR1294]; Immunohistochemical analysis of paraffin-embedded Human brain tissue labelled with TA307647 at 1/100 dilution.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-TrkB antibody [EPR1294](TA307647); Immunohistochemical analysis of paraffin embedded normal Human breast tissue using TA307647 showing -ve staining.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-TrkB antibody [EPR1294](TA307647); Immunohistochemical analysis of paraffin embedded normal Human colon tissue using TA307647 showing -ve staining.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-TrkB antibody [EPR1294](TA307647); Immunohistochemical analysis of paraffin embedded normal Human liver tissue using TA307647 showing -ve staining.
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