Home All anti-NTRK1 antibodies
Anti-NTRK1 Antibody EP1058Y
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Also for NTRK1 (NM_002529)
|A synthetic peptide corresponding to residues surrounding tyrosine 791 of human Trk A was used as an immunogen. This antibody detects both phosphorylated and unphosphorylated Trk A.|
|Human, Mouse, Rat
|WB, IHC, IF
||WB: 1:2500; IHC: 1: 100; ICC: 1: 100; FC: 1:30; IP: 1:50
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), transcript variant 2|
|MTC; p140-TrkA; TRK; Trk-A; TRK1; TRKA|
|The Trk proto-oncogene encodes a 140 kDa, membrane-spanning protein tyrosine kinase that is expressed only in neural tissues. Nerve growth factor (NGF) stimulates phosphorylation of Trk A in neural cell lines and in embryonic dorsal root ganglia. Affinity cross-linking and equilibrium binding experiments with 125I-labeled NGF indicate that Trk A binds NGF specifically in cultured cells with a dissociation constant of 10(-9) molar. The identification of Trk A as an NGF receptor indicates that this protein participates in the primary signal transduction mechanism of NGF (1). Trk A was found to be expressed in the nervous system and phosphorylated in response to NGF (Nerve Growth Factor). Somatic rearrangement(s) of the TRKA gene (also designated NTRK1) are responsible for formation of some oncogenes (2). Trk A is expressed in neural and nonneuronal tissues. Like RET, Trk A is often activated by rearrangements that involve one of at least five other genes in papillary thyroid carcinoma (PTC) (3). |
MAPK signaling pathway
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Western blot analysis on rat brain cell lysate using anti-Trk A, dilution 1:5000. Cells were either (A) untreated or (B) treated with AP.
Immunohistochemical analysis of paraffin-embedded human brain using anti-TRKA
Immunofluorescent staining od SHSY5Y cells using anti-TRKA.