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Anti-NRG3 Antibody EPR4148


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against Neuregulin 3(clone EPR4148)
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the cytoplasmic domain of human Neuregulin 3 was used as an immunogen.
Clone NameEPR4148 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, FC Suggested DilutionsWB: 1:1000 - 1:10000; FC: 1:10 - 1:100
Predicted MW Explanation 77 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens neuregulin 3 (NRG3), transcript variant 1
Alternative NameHRG3; pro-NRG3
Database LinkNP_001010848
Entrez Gene 10718 Human
Entrez Gene 18183 Mouse
Entrez Gene 498596 Rat
FunctionNeuregulin 3, or FBNRG3, is a member of the neuregulin family. This family consists of ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. Neuregulin 3 has been shown to activate tyrosine phosphorylation of its cognate receptor, ERBB4, and it is thought to influence neuroblast proliferation, migration and differentiation by signaling through ERBB4. Neuregulin 3 also promotes mammary differentiation during embryogenesis. Studies have implicated this protein in schizophrenia and schizoaffective disorder (1).
Related PathwayTransmembraneDruggable Genome ErbB signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - NRG3 antibody [EPR4148]; All lanes : Anti-NRG3 antibody [EPR4148] at 1/1000 dilution.Lane 1 : Fetal brain lysate.Lane 2 : SH-SY5Y lysate.Lane 3 : C6 lysate.Lane 4 : Mouse brain lysate.Lane 5 : Rat brain lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 77 kDa.Observed band size : 56 kDa .
FC Image
Flow Cytometry - NRG3 antibody [EPR4148]; Flow cytometric analysis of permeabilized C6 cells using TA307640 (red) or a rabbit IgG (negative) (green).


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