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Anti-NRG3 Antibody EPR4148
Also for NRG3 (NM_001010848)
|A synthetic peptide corresponding to residues in the cytoplasmic domain of human Neuregulin 3 was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; FC: 1:10 - 1:100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for ICC,IHC-P or IP.
|Homo sapiens neuregulin 3 (NRG3), transcript variant 1|
|Neuregulin 3, or FBNRG3, is a member of the neuregulin family. This family consists of ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. Neuregulin 3 has been shown to activate tyrosine phosphorylation of its cognate receptor, ERBB4, and it is thought to influence neuroblast proliferation, migration and differentiation by signaling through ERBB4. Neuregulin 3 also promotes mammary differentiation during embryogenesis. Studies have implicated this protein in schizophrenia and schizoaffective disorder (1).|
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Western blot - NRG3 antibody [EPR4148]; All lanes : Anti-NRG3 antibody [EPR4148] at 1/1000 dilution.Lane 1 : Fetal brain lysate.Lane 2 : SH-SY5Y lysate.Lane 3 : C6 lysate.Lane 4 : Mouse brain lysate.Lane 5 : Rat brain lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 77 kDa.Observed band size : 56 kDa .
Flow Cytometry - NRG3 antibody [EPR4148]; Flow cytometric analysis of permeabilized C6 cells using ab109256 (red) or a rabbit IgG (negative) (green).