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Anti-NR4A1 Antibody EPR3209
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Also for NR4A1 (NM_002135)
|A synthetic peptide corresponding to residues near the N-terminus of human Nur77 was used as an immunogen.|
|Human, Mouse, Rat
|Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.|
|Homo sapiens nuclear receptor subfamily 4, group A, member 1 (NR4A1), transcript variant 1|
|GFRP1; HMR; N10; NAK-1; NGFIB; NP10; NUR77; TR3|
|Nur77 (TR3, NGFI-B) is an orphan nuclear receptor belonging to the steroid/thyroid hormone receptor superfamily with multiple cell functions relating to apoptosis, cell differentiation, and proliferation. Nur77 expression is rapidly induced by several growth factors, mitogens, and stress factors (1). With its central DNA binding domain, Nur77 binds to specific DNA elements and regulates the transcription of the target gene (2). While Nur77 activities are shown to be specific to its sub-cellular location, the phospholyation on Nur77 by various kinases (e.g. RSK, MSK) might affect its transactivation activity and its localization (3, 4). Nur77 localized in the nucleus functions as an oncogenic survival factor and promotes cell growth. However, in mitochondria, it functions as an apoptosis factor after binding to Bcl-2 and triggering cytochrome c release. Nur77 has been linked to apoptosis of immature T cell and T cell hybridoma. In tumors, it is involved in both apoptosis and proliferation of cancer cells (4).|
MAPK signaling pathway
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Western blot analysis on (A) SH-SY5Y and (B) HepG2 on cell lysates using anti-Nur77 RabMAb .
Flow cytometric analysis of permeabilized HepG2 cells using anti- Nur77 RabMAb (red) or a rabbit IgG (negative) (green).