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Anti-NR1H3 Antibody


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SKU Description Amount Price Availability*  
TA306911 Rabbit Polyclonal LXR-A Antibody 100ug $325 3-7 Days
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OriGene Data

ImmunogenLXR-A antibody was raised against a 15 amino acid peptide from near the amino terminus human LXR-A.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens nuclear receptor subfamily 1, group H, member 3 (NR1H3), transcript variant 2
Alternative NameLXR-a; LXRA; RLD-1
Database LinkNP_001123573
Entrez Gene 10062 Human
Entrez Gene 22259 Mouse
Entrez Gene 58852 Rat
FunctionLXR-A belongs to the Liver X Receptor family that encodes highly homologous transcription factors. Like the highly homologous LXR-B, LXR-A forms heterodimers with the retinoic acid receptor RXRalpha, function as sensors for cellular oxysterols which when activated, increase the expression of genes that control sterol and fatty acid metabolism and homeostasis. Recent experiments have indicated that the LXRs can also modulate both innate and adaptive immune responses. Human and mouse tumors produce LXR ligands that inhibit CCR7 expression on maturing dendritic cells (DCs), thereby allowing tumor immunoescape. In mouse models, it was shown that ablating LXR-A signaling led to an immune-mediated strong inhibition of tumor growth, suggesting that manipulation of this pathway may be a viable anti-cancer approach.
Related PathwayNuclear Hormone ReceptorTranscription FactorsDruggable Genome PPAR signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of LXR-A in rat liver tissue lysate with LXR-A antibody at (A) 1 and (B) 2 ug/mL.

IHC Image
Immunohistochemistry of LXR-A in rat liver tissue with LXR-A antibody at 5 ug/mL.

IF Image
Immunofluorescence of LXR-A in rat liver tissue with LXR-A antibody at 20 ug/mL.


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