Home Antibody All anti-NR0B2 antibodies
Also for NR0B2 (NM_021969)
|Recombinant fragment corresponding to a region within amino acids 64 and 257 of NR0B2 (Uniprot ID#Q15466)|
|Human (Predicted: Mouse)
||Lot dependent; please refer to CoA along with shipment
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Mouse (80%)
|Homo sapiens nuclear receptor subfamily 0, group B, member 2 (NR0B2)|
Entrez Gene 8431 Human
Entrez Gene 23957 Mouse
|The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq]|
|Transcription FactorsDruggable Genome |
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Immunohistochemical analysis of paraffin-embedded SW480 Xenograft, using NR0B2(TA308392) antibody at 1:100 dilution.
Immunofluorescence analysis of paraformaldehyde-fixed A431, using NR0B2(TA308392) antibody at 1:500 dilution.