Home Antibody All anti-NPHS1 antibodies
Also for NPHS1 (NM_004646)
|Nephrin antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human Nephrin.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens nephrosis 1, congenital, Finnish type (nephrin) (NPHS1)|
|CNF; nephrin; NPHN|
|Nephrin is strongly expressed in renal glomeruli and is a member of the immunoglobulin family of cell adhesion molecules. Mutations in the Nephrin gene result in congenital nephrotic syndrome, an autosomal-recessive disorder characterized by massive proteinuria in utero and nephrosis at birth. Renal glomeruli allow normal kidneys to filter plasma so that it is very pure. Nephrin is expressed in the podocyte slit-diaphragm of the renal glomeruli in a manner that suggests that Nephrin molecules homodimerize in an anti-parallel fashion similar to cadherin interactions in adherens junctions. Thus, Nephrin may constitute the entire extracellular structure of the slit-diaphragm. Despite its predicted molecular weight, Nephrin often migrates at a lower than expected size in SDS-PAGE.|
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Western blot analysis of Nephrin in mouse kidney tissue lysate with Nephrin antibody at 1 ug/ml in the (A) absence and (B) presence of blocking peptide.
Immunohistochemistry of Nephrin in mouse kidney tissue with Nephrin antibody at 1 ug/ml.