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Home Antibody All anti-NPAS3 antibodies

Anti-NPAS3 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA306417 Rabbit Polyclonal NPAS3 Antibody 100ug $325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenNPAS3 antibody was raised against a 28 amino acid peptide from near the amino terminus of human NPAS3.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 2 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens neuronal PAS domain protein 3 (NPAS3), transcript variant 1
Alternative NamebHLHe12; MOP6; PASD6
Database LinkNP_001158221
Entrez Gene 64067 Human
Entrez Gene 27386 Mouse
Entrez Gene 299016 Rat
FunctionNeuronal PAS domain protein 3 (NPAS3) is a brain-enriched basic helix-loop-helix PAS domain transcription factor and is broadly expressed in the developing neuroepithelium and has recently found to be disrupted by genetic translocation in a family affected with schizophrenia. It was recently shown to be involved in the regulation of FGF signaling in the dentate gyrus by controlling the expression of the FGF receptor subtype 1 and in turn neurogenesis emanating from this region. NPAS3-null mice were growth-retarded and displayed brain defects that included reduced size of the anterior hippocampus, hypoplasia of the corpus callosum, and enlargement of the ventricles, as well as several behavioral abnormalities. Furthermore, these NPAS3-null mice also exhibited disruptions in several neurosignaling pathways involving glutamate, dopamine, and serotonin. These results demonstrate the essential role played by NPAS3 during structural and functional brain development. At least three isoforms of NPAS3 are known to exist.
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of NPAS3 in SK-N-SH cell lysate with NPAS3 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
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Immunohistochemistry of NPAS3 in human brain tissue with NPAS3 antibody at 5 ug/ml.
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