Nop10 is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA2 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. The four H/ACA snoRNP proteins are also components of the telomerase complex (1).
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