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Home Antibody All anti-NOL3 antibodies

Anti-NOL3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA305985
  • Rabbit Polyclonal ARC Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC401296) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for NOL3 (NM_003946)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenARC antibody was raised against a peptide corresponding to amino acids 191 to 208 of human origin.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens nucleolar protein 3 (apoptosis repressor with CARD domain) (NOL3), transcript variant 2
Alternative NameARC; FCM; MYP; NOP; NOP30
Database LinkNP_003937
FunctionApoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD domain containing cell death regulators include RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD (1). ARC interacts with caspase-2 and –8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3. The messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue (1).
Related Pathway

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WB Image
Western blot analysis of ARC in HeLa (H), KB (K), and A549 (A) whole cell lysates with ARC antibody at 1:1000 dilution. 1st Below: Immunohistochemistry of ARC in human heart tissue at 5 µg/ml. 2nd Below: Immunohistochemistry of ARC in human skeletal muscle with ARC antibody at 5 µg/ml.
IHC Image
Immunohistochemistry of ARC in human skeletal muscle with ARC antibody at 5 ug/ml.

 

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