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Home Antibody All anti-NOD2 antibodies

Anti-NOD2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306091
  • Rabbit Polyclonal NOD2 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC411732) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IF(1)

OriGene Data

ImmunogenRabbit NOD2 polyclonal antibody was raised against a synthetic peptide corresponding to 16 amino acids at the amino terminus of human NOD2.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 - 4 ug/ml, IHC: 5 ug/ml, IF: 10 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Immunoaffinity chromatography purified IgG

Reference Data

Target NameHomo sapiens nucleotide-binding oligomerization domain containing 2 (NOD2), transcript variant 1
Alternative NameACUG; BLAU; CARD15; CD; CLR16.3; IBD1; NLRC2; NOD2B; PSORAS1
Database LinkNP_071445
Entrez Gene 64127 Human
FunctionApaf-1 and NOD1 are members of a new family (1), which are involved in the regulation of apoptosis and immune response. Each of them contains a caspase recruitment domain (CARD) and a nucleotide-binding oligomerization domain (NOD). A third member in this family was recently identified and designated NOD2 (2). NOD2 interacts with RICK via a homophilic CARD-CARD interaction. NOD2 activates NF-kappaB, which is regulated by its carboxy-terminal leucine-rich repeat domain that acts as an intracellular receptor for components of bacteria. The variants of NOD2, either a frameshift or a missense, were associated with Crohn’s disease (3,4) that is a main type of chronic inflammatory bowel disease.
Related PathwayDruggable Genome NOD-like receptor signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of NOD2 in Jurkat cell lysate with NOD2 antibody at (A) 1, (B) 2 and (C) 4 ug/mL.
IF Image
Immunocytochemistry of NOD2 in Jurkat cells with NOD2 antibody at 5 ug/mL.

 

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