Home Antibody All anti-NLRP1 antibodies
Also for NLRP1 (NM_001033053)
|NALP1 antibody was raised against a peptide corresponding to 13 amino acids near the carboxy-terminus of human NALP1.|
||ELISA, WB: 1 - 4 ug/ml, ICC: 10 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Immunoaffinity chromatography purified IgG
|Homo sapiens NLR family, pyrin domain containing 1 (NLRP1), transcript variant 5|
|CARD7; CIDED; CLR17.1; DEFCAP; DEFCAP-L/S; NAC; NALP1; PP1044; SLEV1; VAMAS1|
Entrez Gene 22861 Human
|NALP1 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli (1). It contains a caspase recruitment domain (CARD) in addition to a NACHT domain and leucine rich repeat (LRR). This protein interacts strongly with caspase 2 and weakly with caspase 9, as well as with Apaf-1 (2). Transient overexpression of this gene in cultured cells was sufficient to induce apoptosis (3). NALP1 mRNA and protein expression levels in myeloid leukemia cells are increased following CREB (cAMP-response element binding protein) activation, suggesting that NALP1 may contribute to modulate the response of these cells to pro-inflammatory stimuli (4). Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for NALP1 (3).|
|Druggable Genome NOD-like receptor signaling pathway|
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Western blot analysis of NALP1 in U937 cell lysate with NALP1 antibody at (A) 1, (B) 2 and (C) 4 ug/mL.
Immunocytochemistry of NALP1 in K562 cells with NALP1 antibody at 10 ug/mL.